Person self-administering Spravato esketamine nasal spray under clinical supervision

Spravato (Esketamine) Therapy Coming Soon

The Ketamine Clinic of Hawaii is now REMS certified to offer Spravato and will be offering it soon in our Honolulu clinic.

Contact Us

Spravato Esketamine Nasal Spray


What Spravato Is

Spravato is FDA-approved specifically for treatment-resistant depression and for depression with suicidal ideation, and can now be used as a standalone treatment. Most major insurance plans, including Medicare, cover it in some form, and our team will verify your specific benefits before you begin. You can ask about Spravato or IV ketamine in the same consultation, and our team will help you understand which path fits your situation.

FDA-Approved Indication

Spravato is approved specifically for treatment-resistant depression in adults who have not responded to at least two prior antidepressants, and for major depressive disorder with acute suicidal thoughts or behavior.

How It’s Administered

Spravato is a self-administered nasal spray, given under direct in-office supervision at a REMS-certified treatment center. Patients are monitored for at least two hours after each dose to watch for changes in blood pressure, heart rhythm, or sedation.

Typical Treatment Schedule

Most patients start with two sessions per week for the first four weeks, then taper to weekly or biweekly maintenance sessions based on response.

How to Get Esketamine Nasal Spray

Getting started with Spravato works the same way as scheduling IV ketamine therapy at our clinic. Fill out our consultation form or give us a call, and our clinical team will schedule an evaluation to determine whether Spravato is the right fit for you. We are REMS certified to offer Spravato and will be doing so very soon.

During your consultation, we will review your medical history, discuss your treatment goals, and help you understand whether Spravato, IV ketamine, or both make sense for your situation. We will also verify your insurance benefits, since most major plans, including Medicare, cover Spravato in some form, with your specific out-of-pocket cost depending on your individual plan.


Spravato (Esketamine) Prices in Hawaii

The difference in Spravato pricing and costs comes down to your individual insurance plan, whether your deductible has been met, and how your visit is billed. We’ll verify your specific benefits before you begin treatment, so you know what to expect.

Spravato Without Insurance

Spravato typically costs between $700 and $1,000 per session when paid out of pocket, depending on dosage and monitoring requirements.

Spravato With Insurance

Most major insurance plans, including Medicare, cover Spravato in some form. Depending on your specific plan and deductible status, your out-of-pocket cost per visit can range from as little as $0 to $50, up to a few hundred dollars in some cases.

Strict Monitoring

Spravato and IV ketamine are monitored differently because they’re delivered differently. Spravato is a self-administered nasal spray that must be given and observed in a REMS-certified clinical setting; patients are never permitted to take it home. IV ketamine is delivered as a continuous infusion with monitoring throughout the treatment itself. Both approaches are designed around the same goal: making sure you’re safe throughout your visit.

How We Approach Safety

Ketamine Clinic of Hawaii has over a decade of experience administering ketamine in a clinical setting. Safety is central to how we operate, and that standard extends to every treatment we offer, including Spravato.

A Medically Trained Team

Our clinical staff bring backgrounds in acute and surgical care, including direct experience using ketamine in operating room settings. That medical foundation, not a psychiatry-only model, is part of how we approach safety for both Spravato and IV ketamine.

Contact the Ketamine Clinic of Hawaii

If you have questions about ketamine infusion therapy or would like to request more information about evaluation, eligibility, or treatment options, please complete the form below. A member of our clinical team will review your message and respond as appropriate. Submission of this form does not establish a physician–patient relationship.

Decades of Clinical Experience With Ketamine

Ketamine is not new to us. Long before ketamine entered broader mental health care, it was a routine and trusted medication in surgical medicine. Our physicians have used ketamine safely for decades in operating rooms, including plastic and reconstructive surgery, where precise dosing, monitoring, and patient stability are critical.

Hawaii's First Ketamine Clinic

We were the first ketamine clinic in Hawaii and among the earliest in the United States to offer ketamine therapy in a dedicated clinical setting. That history matters. Our approach is grounded in real-world medical use, not trends or experimentation. Every protocol we use today is informed by years of surgical experience, clinical judgment, and patient safety standards developed in hospital environments.

This foundation distinguishes our care. Ketamine therapy here reflects long-standing medical practice, applied carefully to modern therapeutic use.

Ketamine Clinic Hours

Monday 9:00AM – 4:30PM
Tuesday 9:00AM – 4:30PM
Wednesday 9:00AM – 4:30PM
Thursday 9:00AM – 4:30PM
Friday 9:00AM – 4:30PM
Saturday 9:00AM – 1:00PM
Sunday Closed

If your suffering from chronic pain, severe depression, PTSD or addiction and your interested in Ketamine infusion treatment, give us a call or email us!

Call Now

Our Location

Ketamine Clinic of Hawaii
677 Ala Moana Blvd Suite 1023
Honolulu, Hawaii 96813
Phone: 808-945-5433